Imprinting Articles : Fetal Origins of Disease

Below are selected articles on genomic imprinting organized by subject. Select a subject by clicking its tab. Hover over each article's title to view its abstract, and click the title to view its full PubMed record. Corresponding authors follow the author list, and fulltext PDFs are available for some articles and reviews.

• Imprinted Genes
• Regulation
• Cancer
• Developmental Disorders
• Fetal Origins of Disease
• Epigenetics
• Evolution

• Bisphenol a exposure disrupts genomic imprinting in the mouse
  Susiarjo M, Sasson I, Mesaros C, Bartolomei MS
  PLoS Genet 9:e1003401 (2013)
• Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes
  Court F, Martin-Trujillo A, Romanelli V, Garin I, Iglesias-Platas I, Salafsky I, Guitart M, Perez de Nanclares G, Lapunzina P, Monk D
  Hum Mutat 34:595-602 (2013)
• Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
  Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A, Kurtzberg J, Jirtle RL, Murphy SK, Hoyo C
  BMC Med 11:29 (2013)
• Adaptive radiation-induced epigenetic alterations mitigated by antioxidants
  Bernal AJ, Dolinoy DC, Huang D, Skaar DA, Weinhouse C, Jirtle RL [Randy Jirtle]
  FASEB J 27:665-671 (2013)
  → Feature Article and Press Reports
• Review: Understanding transgenerational epigenetic inheritance via the gametes in mammals
  Daxinger L, Whitelaw E
  Nat Rev Genet 13:153-62 (2012)
• Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
  Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y
  Science 333:1300-3 (2011)
• A Model for Genomic Imprinting in the Social Brian: Juveniles
  Ubeda F, Gardner A
  Evolution (Apr 2010)
• A role for the elongator complex in zygotic paternal genome demethylation
  Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y [Yi Zhang]
  Nature 463:554-8 (2010)
• Abnormal methylation at the KvDMR1 imprinting control region in clinically normal children conceived by assisted reproductive technologies
  Gomes MV, Huber J, Ferriani RA, Amaral Neto AM, Ramos ES [MV Gomes]
  Mol Hum Reprod 15:471-7 (2009)
• Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model
  Sharma A, Singh P
  PLoS ONE 4:e5763 (2009)
• Interview Epigenomics, imprinting and disease susceptibility
  Jirtle RL [R Jirtle]
  Pharmacogenomics 9:1791-5 (2008)
  Fulltext (PDF)
• The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome
  Dolinoy DC
  Nutr Rev 66 Suppl 1:S7-11 (2008)
• Randy L Jirtle, PhD: epigenetics a window on gene dysregulation, disease Interview by Bridget M Kuehn
  Kuehn BM
  JAMA 299:1249-250 (2008)
  Fulltext (PDF)
• Review: Environmental epigenomics in human health and disease
  Dolinoy DC, Jirtle RL [RL Jirtle]
  Environ Mol Mutagen 49:4-8 (2008)
  Fulltext (PDF)
• Computational and Experimental Identification of Novel Human Imprinted Genes
  Luedi PE, Dietrich FS , Weidman JR, Bosko JM, Jirtle RL, Hartemink AJ [A.J. Hartemink] [R.L. Jirtle]
  Genome Res. 17: (2007)
  Fulltext (PDF)Supplement (PDF)→ Feature Article and Press Reports
• Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia
  Shimabukuro M, Sasaki T, Imamura A, Tsujita T, Fuke C, Umekage T, Tochigi M, Hiramatsu K, Miyazaki T, Oda T, Sugimoto J, Jinno Y, Okazaki Y
  J Psychiatr Res 41:1042-6 (2007)
• Review: Epigenetic Epidemiology of the Developmental Origins Hypothesis
  Waterland RA, Michels KB
  Annu Rev Nutr 27:363-388 (2007)
• Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease
  Drake AJ, Tang JI, Nyirenda MJ
  Clin Sci (Lond) 113:219-32 (2007)
• Suboptimal in vitro culture conditions: an epigenetic origin of long-term health effects
  Fernández-Gonzalez R, Ramirez MA, Bilbao A, De Fonseca FR, Gutiérrez-Adán A
  Mol Reprod Dev 74:1149-56 (2007)
• Review: Metastable epialleles, imprinting, and the fetal origins of adult diseases
  Dolinoy DC, Das R, Weidman JR, Jirtle RL
  Pediatr Res 61:30R-37R (2007)
  Fulltext (PDF)
• Review: Imprinted and More Equal
  Jirtle RL, Weidman JR [RL Jirtle]
  Am Sci 95:143-149 (2007)
  Fulltext (PDF)→ Feature Article and Press Reports
• Review: Environmental epigenomics and disease susceptibility
  Jirtle RL, Skinner MK
  Nat Rev Genet 8:253-62 (2007)
  Fulltext (PDF)
• Methylation pattern at the KvDMR in a child with Beckwith-Wiedemann syndrome conceived by ICSI
  Gomes MV, Gomes CC, Pinto W, Ramos ES
  Am J Med Genet A 143:625-9 (2007)
• Bacterial infection promotes DNA hypermethylation
  Bobetsis YA, Barros SP, Lin DM, Weidman JR, Dolinoy DC, Jirtle RL, Boggess KA, Beck JD, Offenbacher S
  J Dent Res 86:169-74 (2007)
  Fulltext (PDF)
• Review: DNA is not Destiny
  Ethan Watters
  Discover 27:32-7 (2006)
  Fulltext (PDF)
• Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome
  Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL [RL Jirtle]
  Environ Health Perspect 114:567-72 (2006)
  Fulltext (PDF)→ Feature Article and Press Reports
• Schizophrenia, cancer and imprinting: early nutritional influences
  Abel KM, Allin MP, Jirtle RL
  Br J Psychiatry 188:394 (2006)
  Fulltext (PDF)
• Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
  Waterland RA, Lin JR, Smith CA, Jirtle RL
  Hum Mol Genet 15:705-16 (2006)
  Fulltext (PDF)
• Genome-wide prediction of imprinted murine genes
  Luedi PP, Hartemink AJ, Jirtle RL [RL Jirtle]
  Genome Res 15:875-84 (2005)
  Fulltext (PDF)Supplement (PDF)→ Feature Article and Press Reports
• Review: The developmental origins of adult disease
  Barker DJ
  J Am Coll Nutr 23:588S-595S (2004)
• The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding
  Plagge A, Gordon E, Dean W, Boiani R, Cinti S, Peters J, Kelsey G [G Kelsey]
  Nat Genet 36:818-26 (2004)
• Review: Are children born after assisted reproductive technology at increased risk for adverse health outcomes?
  Schieve LA, Rasmussen SA, Buck GM, Schendel DE, Reynolds MA, Wright VC [LA Schieve]
  Obstet Gynecol 103:1154-63 (2004)
• Genomic imprinting in disruptive spermatogenesis
  Marques CJ, Carvalho F, Sousa M, Barros A [M Sousa]
  Lancet 363:1700-2 (2004)
• Epigenetics and assisted reproductive technology: a call for investigation
  Niemitz EL, Feinberg AP [AP Feinberg]
  Am J Hum Genet 74:599-609 (2004)
  → Feature Article and Press Reports
• The molecular biology of Wilms tumour
  Brown KW, Malik KT [KW Brown] [KT Malik]
  Expert Rev Mol Med 2001:1-16 (2001)
  Fulltext (PDF)
• Review: Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
  Waterland RA, Jirtle RL [RL Jirtle]
  Nutrition 20:63-8 (2004)
  Fulltext (PDF)
• Transposable elements: targets for early nutritional effects on epigenetic gene regulation
  Waterland RA, Jirtle RL [RL Jirtle]
  Mol Cell Biol 23:5293-300 (2003)
  Fulltext (PDF)→ Feature Article and Press Reports
• In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene
  Gicquel C, Gaston V, Mandelbaum J, Siffroi JP, Flahault A, Le Bouc Y [C Gicquel]
  Am J Hum Genet 72:1338-41 (2003)
• Review: Imprinting evolution and the price of silence
  Murphy SK, Jirtle RL [RL Jirtle]
  Bioessays 25:577-88 (2003)
  Fulltext (PDF)→ Feature Article and Press Reports
• Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic semen injection
  Ørstavik KH, Eiklid K, van der Hagen CB, Spetalen S, Kierulf K, Skjeldal O, Buiting K [KH Ørstavik]
  Am J Hum Genet 72:218-9 (2003)
• Beckwith-Wiedemann syndrome and assisted reproduction technology (ART)
  Maher ER, Brueton LA, Bowdin SC, Luharia A, Cooper W, Cole TR, Macdonald F, Sampson JR, Barratt CL, Reik W, Hawkins MM [ER Maher]
  J Med Genet 40:62-4 (2003)
• Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19
  DeBaun MR, Niemitz EL, Feinberg AP [AP Feinberg]
  Am J Hum Genet 72:156-60 (2003)
• Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations
  Killian JK, Oka Y, Jang HS, Fu X, Waterland RA, Sohda T, Sakaguchi S, Jirtle RL [RL Jirtle]
  Hum Mutat 18:25-31 (2001)
  Fulltext (PDF)
• Review: Genomic imprinting: parental influence on the genome
  Reik W, Walter J [W Reik] [J Walter]
  Nat Rev Genet 2:21-32 (2001)
• Maternal methylation imprints on human chromosome 15 are established during or after fertilization
  El-Maarri O, Buiting K, Peery EG, Kroisel PM, Balaban B, Wagner K, Urman B, Heyd J, Lich C, Brannan CI, Walter J, Horsthemke B [J Walter]
  Nat Genet 27:341-4 (2001)
• Review: Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote
  Reik W, Walter J [W Reik] [J Walter]
  Nat Genet 27:255-6 (2001)
• Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior
  Murphy SK, Wylie AA, Jirtle RL [RL Jirtle]
  Genomics 71:110-7 (2001)
  Fulltext (PDF)→ Feature Article and Press Reports
• Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
  Young LE, Fernandes K, McEvoy TG, Butterwith SC, Gutierrez CG, Carolan C, Broadbent PJ, Robinson JJ, Wilmut I, Sinclair KD [LE Young]
  Nat Genet 27:153-4 (2001)
• Review: Imprinted genes, cognition and behaviour
  Isles AR, Wilkinson LS [LS Wilkinson]
  Trends Cogn Sci 4:309-318 (2000)
• Review: Imprinting, the X-chromosome, and the male brain: explaining sex differences in the liability to autism
  Skuse DH [DH Skuse]
  Pediatr Res 47:9-16 (2000)
• Regulation of maternal behavior and offspring growth by paternally expressed Peg3
  Li L, Keverne EB, Aparicio SA, Ishino F, Barton SC, Surani MA [MA Surani]
  Science 284:330-3 (1999)
• Review: Genomic imprinting: implications for human disease
  Falls JG, Pulford DJ, Wylie AA, Jirtle RL [RL Jirtle]
  Am J Pathol 154:635-47 (1999)
  Fulltext (PDF)
• Review: Polymorphisms, genomic imprinting and cancer susceptibility
  Pulford DJ, Falls JG, Killian JK, Jirtle RL [RL Jirtle]
  Mutat Res 436:59-67 (1999)
  Fulltext (PDF)
• Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest
  Lefebvre L, Viville S, Barton SC, Ishino F, Keverne EB, Surani MA [MA Surani]
  Nat Genet 20:163-9 (1998)

Copyright © 2012, Randy L. Jirtle, PhD. All rights reserved. Website by James Jirtle; header art by Collin Murphy | Contact Us