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KCNK9 Imprinting & TNBC

KCNK9 is imprinted in the human brain (Luedi et al, 2007), and also expressed normally only from the maternal allele in breast epithelium (Skaar et al, 2021). The differentially methylated region (DMR) controlling its imprint status is hypomethylated in 63% of triple-negative breast cancers (TNBC), resulting in biallelic expression of TASK3 protein and resistance to apoptosis.